Cargando…

Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via microdomain and lipid raft organization. Several co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeitler, Stefanie, Schumacher, Fabian, Monti, Juliana, Anni, Daniela, Guhathakurta, Debarpan, Kleuser, Burkhard, Friedland, Kristina, Fejtová, Anna, Kornhuber, Johannes, Rhein, Cosima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698877/ https://www.ncbi.nlm.nih.gov/pubmed/33218173 http://dx.doi.org/10.3390/cells9112502

Ejemplares similares

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels
por: Dryer, Stuart E., et al.
Publicado: (2018)

Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation
por: Anni, Daniela, et al.
Publicado: (2021)

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel
por: Graham, Sarabeth, et al.
Publicado: (2010)

Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s
por: Ko, Juyeon, et al.
Publicado: (2017)

mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment
por: Rhein, Cosima, et al.
Publicado: (2021)

Transient Receptor Potential Canonical 6 (TRPC6) Channel in the Pathogenesis of Diseases: A Jack of Many Trades
por: Saqib, Uzma, et al.
Publicado: (2023)

Development and Application of Automatized Routines for Optical Analysis of Synaptic Activity Evoked by Chemical and Electrical Stimulation
por: Guhathakurta, Debarpan, et al.
Publicado: (2022)

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
por: Chen, Xingjuan, et al.
Publicado: (2020)

20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes
por: Roshanravan, Hila, et al.
Publicado: (2016)

Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
por: Wang, Qian, et al.
Publicado: (2020)

Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain
por: Sun, Zhi-Chuan, et al.
Publicado: (2020)

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
por: Asghar, Muhammad Yasir, et al.
Publicado: (2020)

Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
por: Mishra, Sumita, et al.
Publicado: (2023)

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis
por: Börtlein, Charlene, et al.
Publicado: (2019)

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants
por: Rhein, Cosima, et al.
Publicado: (2012)

Examining the role of transient receptor potential canonical 5 (TRPC5) in osteoarthritis
por: de Sousa Valente, João, et al.
Publicado: (2020)

Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels
por: Cole, Bethan A., et al.
Publicado: (2023)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca(2+) Influx
por: Schindl, Rainer, et al.
Publicado: (2012)

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
por: Sexton, Jane E., et al.
Publicado: (2016)

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP
por: Montenegro‐Venegas, Carolina, et al.
Publicado: (2022)

Computational Pipeline for NIRS-EEG Joint Imaging of tDCS-Evoked Cerebral Responses—An Application in Ischemic Stroke
por: Guhathakurta, Debarpan, et al.
Publicado: (2016)

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels
por: Kim, Jinsung, et al.
Publicado: (2019)

Inhibition of acid sphingomyelinase increases regulatory T cells in humans
por: Wiese, Teresa, et al.
Publicado: (2021)

Acid Sphingomyelinase Is a Modulator of Contextual Fear
por: Zoicas, Iulia, et al.
Publicado: (2022)

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
por: Naser, Eyad, et al.
Publicado: (2020)

Regulation of hematogenous tumor metastasis by acid sphingomyelinase
por: Carpinteiro, Alexander, et al.
Publicado: (2015)

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels
por: Ahmad, Azmi A., et al.
Publicado: (2020)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism
por: Zoicas, Iulia, et al.
Publicado: (2023)

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6
por: Liu, Lu, et al.
Publicado: (2020)

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
por: Meiners, Jana, et al.
Publicado: (2019)

Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation
por: Alawi, Khadija M, et al.
Publicado: (2017)

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging‐associated tumorigenesis induced by ultraviolet B
por: Hsu, Wen‐Li, et al.
Publicado: (2019)

Characterization of a Neutral Sphingomyelinase Activity in Human Serum and Plasma
por: Mühle, Christiane, et al.
Publicado: (2023)

TRPC6 is altered in COVID-19 pneumonia
por: Leidinger, Gina, et al.
Publicado: (2022)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hs9hdtl7hteck7epl27o2k4685