PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells

Liver fibrosis represents the wound healing response to sustained hepatic injury with activation of hepatic stellate cells (HSCs). The I148M variant of the PNPLA3 gene represents a risk factor for development of severe liver fibrosis. Activated HSCs carrying the I148M variant display exacerbated pro...

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Detalles Bibliográficos
Autores principales: Bruschi, Francesca Virginia, Tardelli, Matteo, Einwallner, Elisa, Claudel, Thierry, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698885/
https://www.ncbi.nlm.nih.gov/pubmed/33218077
http://dx.doi.org/10.3390/ijms21228711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698885/
https://www.ncbi.nlm.nih.gov/pubmed/33218077
http://dx.doi.org/10.3390/ijms21228711

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