Cargando…

PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells

Liver fibrosis represents the wound healing response to sustained hepatic injury with activation of hepatic stellate cells (HSCs). The I148M variant of the PNPLA3 gene represents a risk factor for development of severe liver fibrosis. Activated HSCs carrying the I148M variant display exacerbated pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bruschi, Francesca Virginia, Tardelli, Matteo, Einwallner, Elisa, Claudel, Thierry, Trauner, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698885/ https://www.ncbi.nlm.nih.gov/pubmed/33218077 http://dx.doi.org/10.3390/ijms21228711

Ejemplares similares

PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells
por: Bruschi, Francesca Virginia, et al.
Publicado: (2019)

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M
por: Tardelli, Matteo, et al.
Publicado: (2017)

PNPLA3 expression and its impact on the liver: current perspectives
por: Bruschi, Francesca Virginia, et al.
Publicado: (2017)

Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH
por: Bruschi, Francesca V., et al.
Publicado: (2020)

Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs
por: Tardelli, Matteo, et al.
Publicado: (2018)

Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice
por: Tardelli, Matteo, et al.
Publicado: (2021)

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
por: Smagris, Eriks, et al.
Publicado: (2015)

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease
por: Tardelli, Matteo, et al.
Publicado: (2020)

PNPLA3 I148M associations with liver carcinogenesis in Japanese chronic hepatitis C patients
por: Nakaoka, Kazunori, et al.
Publicado: (2015)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
por: Rady, Brian, et al.
Publicado: (2021)

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
por: Pirazzi, Carlo, et al.
Publicado: (2014)

PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma
por: Valenti, Luca, et al.
Publicado: (2013)

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL
por: Witzel, Hagen Roland, et al.
Publicado: (2022)

Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C
por: De Nicola, Stella, et al.
Publicado: (2014)

Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation
por: Geng, Ning, et al.
Publicado: (2015)

KIAA1363 affects retinyl ester turnover in cultured murine and human hepatic stellate cells
por: Wagner, Carina, et al.
Publicado: (2022)

A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis
por: Rosendahl, Jonas, et al.
Publicado: (2012)

PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease
por: BasuRay, Soumik
Publicado: (2019)

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction
por: Gou, Yusong, et al.
Publicado: (2023)

Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B
por: Hsueh, Rei-Chi, et al.
Publicado: (2022)

PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes
por: Mancina, Rosellina Margherita, et al.
Publicado: (2015)

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls
por: Valenti, Luca, et al.
Publicado: (2012)

The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2014)

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
por: Huang, Yongcheng, et al.
Publicado: (2011)

Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population
por: Li, Yiling, et al.
Publicado: (2012)

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
por: BasuRay, Soumik, et al.
Publicado: (2017)

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
por: Sherman, David J., et al.
Publicado: (2023)

Erratum to: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels
por: Stojkovic, Ivana A., et al.
Publicado: (2016)

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
por: He, Shaoqing, et al.
Publicado: (2010)

Clinically silent LINE 1 insertion in the PNPLA3 gene may impede genotyping of the p.I148M variant
por: Leníček, Martin, et al.
Publicado: (2021)

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality
por: Kim, Hyun-seok, et al.
Publicado: (2022)

The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism
por: Chen, Lizhen, et al.
Publicado: (2017)

Altered profiles of circulating cytokines in chronic liver diseases (NAFLD/HCC): Impact of the PNPLA3 ( I148M ) risk allele
por: Kirchmeyer, Mélanie, et al.
Publicado: (2023)

Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro
por: Hu, Jue, et al.
Publicado: (2015)

Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling
por: Kim, Jieun, et al.
Publicado: (2017)

Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M
por: Rausch, Vanessa, et al.
Publicado: (2016)

PNPLA3 I148M mediates the regulatory effect of NF‐kB on inflammation in PA‐treated HepG2 cells
por: Yuan, Shuhua, et al.
Publicado: (2019)

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women
por: Cherubini, Alessandro, et al.
Publicado: (2023)

Proteomic Changes of Activated Hepatic Stellate Cells
por: Schinagl, Maximilian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bldh4fl8im9sn3ut2m0u6f54bo