The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors

Adeno-Associated Virus is the leading vector for gene therapy. Although it is the vector for all in vivo gene therapies approved for clinical use by the US Food and Drug Administration, its biology is still not yet fully understood. It has been shown that different serotypes of AAV bind to their cel...

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Detalles Bibliográficos
Autores principales: Silveria, Mark A., Large, Edward E., Zane, Grant M., White, Tommi A., Chapman, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698955/
https://www.ncbi.nlm.nih.gov/pubmed/33218165
http://dx.doi.org/10.3390/v12111326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698955/
https://www.ncbi.nlm.nih.gov/pubmed/33218165
http://dx.doi.org/10.3390/v12111326

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