CBMS-02 Phosphoglycerate mutase 1 (PGAM1) controls DNA damage repair via regulation of WIP1 activity

Phosphoglycerate Mutase 1 (PGAM1) is overexpressed in different forms of cancer and has been suggested to have additional functions beyond its role in metabolism. We here report that PGAM1 is overexpressed in GBMs and indirectly regulates activation of ATM, Chk1 and Chk2 but not ATR, thereby increas...

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Detalles Bibliográficos
Autores principales: Ohba, Shigeo, Johannessen, Tor-Christian, Chatla, Kamalakar, Yang, Xiaodong, Hirose, Yuichi, Pieper, Russell, Mukherjee, Joydeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699085/
http://dx.doi.org/10.1093/noajnl/vdaa143.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699085/
http://dx.doi.org/10.1093/noajnl/vdaa143.014

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