The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin

Cholesterol seems to play a central role in the augmentation of saporin-based immunotoxin (IT) cytotoxicity by triterpenoid saponins. Endolysosomal escape has been proposed as one mechanism for the saponin-mediated enhancement of targeted toxins. We investigated the effects of lipid depletion follow...

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Detalles Bibliográficos
Autores principales: Smith, Wendy S., Johnston, David A., Wensley, Harrison J., Holmes, Suzanne E., Flavell, Sopsamorn U., Flavell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699356/
https://www.ncbi.nlm.nih.gov/pubmed/33228031
http://dx.doi.org/10.3390/ijms21228734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699356/
https://www.ncbi.nlm.nih.gov/pubmed/33228031
http://dx.doi.org/10.3390/ijms21228734

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