Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism

AIM: We aimed to systematically examine the effects of enzymatic activity of 38 human CYP2C9 alleles and 21 human CYP3A4 alleles, including wild-type CYP2C9.1 and CYP3A4.1, which contain the 24 CYP2C9 novel alleles (*36–*60) and 6 CYP3A4 novel alleles (*28–*34) newly found in the Chinese population,...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Peng-fei, Zheng, Xiang, Hu, Xiao-xia, Yang, Cheng-cheng, Chen, Zhe, Qian, Jian-chang, Cai, Jian-ping, Hu, Guo-xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699448/
https://www.ncbi.nlm.nih.gov/pubmed/33262574
http://dx.doi.org/10.2147/DDDT.S268796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699448/
https://www.ncbi.nlm.nih.gov/pubmed/33262574
http://dx.doi.org/10.2147/DDDT.S268796

Ejemplares similares