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Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism

AIM: We aimed to systematically examine the effects of enzymatic activity of 38 human CYP2C9 alleles and 21 human CYP3A4 alleles, including wild-type CYP2C9.1 and CYP3A4.1, which contain the 24 CYP2C9 novel alleles (*36–*60) and 6 CYP3A4 novel alleles (*28–*34) newly found in the Chinese population,...

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Detalles Bibliográficos
Autores principales:	Tang, Peng-fei, Zheng, Xiang, Hu, Xiao-xia, Yang, Cheng-cheng, Chen, Zhe, Qian, Jian-chang, Cai, Jian-ping, Hu, Guo-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699448/ https://www.ncbi.nlm.nih.gov/pubmed/33262574 http://dx.doi.org/10.2147/DDDT.S268796

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