Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer

Tumours were recently revealed to undergo a phylostratic and phenotypic shift to unicellularity. As well, aggressive tumours are characterized by an increased proportion of polyploid cells. In order to investigate a possible shared causation of these two features, we performed a comparative phylostr...

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Detalles Bibliográficos
Autores principales: Anatskaya, Olga V., Vinogradov, Alexander E., Vainshelbaum, Ninel M., Giuliani, Alessandro, Erenpreisa, Jekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699474/
https://www.ncbi.nlm.nih.gov/pubmed/33228223
http://dx.doi.org/10.3390/ijms21228759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699474/
https://www.ncbi.nlm.nih.gov/pubmed/33228223
http://dx.doi.org/10.3390/ijms21228759

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