Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to bioreductive activation and free radical generation. In this work, we aimed to clarify the role of NAD(P)H:quinone oxidoreductase...

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Detalles Bibliográficos
Autores principales: Nemeikaitė-Čėnienė, Aušra, Šarlauskas, Jonas, Misevičienė, Lina, Marozienė, Audronė, Jonušienė, Violeta, Lesanavičius, Mindaugas, Čėnas, Narimantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699506/
https://www.ncbi.nlm.nih.gov/pubmed/33228195
http://dx.doi.org/10.3390/ijms21228754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699506/
https://www.ncbi.nlm.nih.gov/pubmed/33228195
http://dx.doi.org/10.3390/ijms21228754

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