Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter

The heterodimeric ATP-binding cassette (ABC) sterol transporter, ABCG5/G8, is responsible for the biliary and transintestinal secretion of cholesterol and dietary plant sterols. Missense mutations of ABCG5/G8 can cause sitosterolemia, a loss-of-function disorder characterized by plant sterol accumul...

Descripción completa

Detalles Bibliográficos
Autores principales: Xavier, Bala M., Zein, Aiman A., Venes, Angelica, Wang, Junmei, Lee, Jyh-Yeuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699580/
https://www.ncbi.nlm.nih.gov/pubmed/33228147
http://dx.doi.org/10.3390/ijms21228747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699580/
https://www.ncbi.nlm.nih.gov/pubmed/33228147
http://dx.doi.org/10.3390/ijms21228747

Ejemplares similares