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Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical management of multiple cancer types, however, many tumors still fail to respond. CCL2 is highly expressed in various cancer types and has been shown to be associated with poor prognosis. Inhibition or blockade of the CC...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699641/ https://www.ncbi.nlm.nih.gov/pubmed/33247183 http://dx.doi.org/10.1038/s42003-020-01441-y |