Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines

The epidermal growth factor receptor (EGFR), through the MAP kinase and PI3K-Akt-mTOR axis, plays a pivotal role in colorectal cancer (CRC) pathogenesis. The membrane-associated NEU3 sialidase interacts with and desialylates EGFR by promoting its dimerization and downstream effectors’ activation. Am...

Descripción completa

Detalles Bibliográficos
Autores principales: Bovio, Federica, Epistolio, Samantha, Mozzi, Alessandra, Monti, Eugenio, Fusi, Paola, Forcella, Matilde, Frattini, Milo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699864/
https://www.ncbi.nlm.nih.gov/pubmed/33233823
http://dx.doi.org/10.3390/ijms21228805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699864/
https://www.ncbi.nlm.nih.gov/pubmed/33233823
http://dx.doi.org/10.3390/ijms21228805

Ejemplares similares