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Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines
The epidermal growth factor receptor (EGFR), through the MAP kinase and PI3K-Akt-mTOR axis, plays a pivotal role in colorectal cancer (CRC) pathogenesis. The membrane-associated NEU3 sialidase interacts with and desialylates EGFR by promoting its dimerization and downstream effectors’ activation. Am...
Autores principales: | Bovio, Federica, Epistolio, Samantha, Mozzi, Alessandra, Monti, Eugenio, Fusi, Paola, Forcella, Matilde, Frattini, Milo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699864/ https://www.ncbi.nlm.nih.gov/pubmed/33233823 http://dx.doi.org/10.3390/ijms21228805 |
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