Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics

The dual inhibitor of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E(2) synthase-1 (mPGES-1), named BRP-187, represents a promising drug candidate due to its improved anti-inflammatory efficacy along with potentially reduced side effects in comparison to non-steroida...

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Detalles Bibliográficos
Autores principales: Behnke, Mira, Vollrath, Antje, Klepsch, Lea, Beringer-Siemers, Baerbel, Stumpf, Steffi, A. Czaplewska, Justyna, Hoeppener, Stephanie, Werz, Oliver, S. Schubert, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699897/
https://www.ncbi.nlm.nih.gov/pubmed/33233853
http://dx.doi.org/10.3390/polym12112751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699897/
https://www.ncbi.nlm.nih.gov/pubmed/33233853
http://dx.doi.org/10.3390/polym12112751

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