Investigation of the Selectivity of L-Type Voltage-Gated Calcium Channels 1.3 for Pyrimidine-2,4,6-Triones Derivatives Based on Molecular Dynamics Simulation

Human Ca(v)1.3 (hCa(v)1.3) is of great interest as a potential target for Parkinson’s disease. However, common medications like dihydropyridines (DHPs), a kind of classic calcium channel blocker, have poor selectivity to hCa(v)1.3 in clinical treatment, mainly due to being implicated in cardiovascul...

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Detalles Bibliográficos
Autores principales: Ye, Qi, Zhang, Zhenyu, Zhang, Wenying, Ding, Yushan, Zhao, Fan, Zhang, Jinghai, Song, Yongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699898/
https://www.ncbi.nlm.nih.gov/pubmed/33233858
http://dx.doi.org/10.3390/molecules25225440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699898/
https://www.ncbi.nlm.nih.gov/pubmed/33233858
http://dx.doi.org/10.3390/molecules25225440

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