Cargando…

Investigation of the Selectivity of L-Type Voltage-Gated Calcium Channels 1.3 for Pyrimidine-2,4,6-Triones Derivatives Based on Molecular Dynamics Simulation

Human Ca(v)1.3 (hCa(v)1.3) is of great interest as a potential target for Parkinson’s disease. However, common medications like dihydropyridines (DHPs), a kind of classic calcium channel blocker, have poor selectivity to hCa(v)1.3 in clinical treatment, mainly due to being implicated in cardiovascul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Qi, Zhang, Zhenyu, Zhang, Wenying, Ding, Yushan, Zhao, Fan, Zhang, Jinghai, Song, Yongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699898/ https://www.ncbi.nlm.nih.gov/pubmed/33233858 http://dx.doi.org/10.3390/molecules25225440

Ejemplares similares

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca(2+) channel activators
por: Ortner, Nadine J., et al.
Publicado: (2014)

Syntheses of Radioiodinated Pyrimidine-2,4,6-Triones as Potential Agents for Non-Invasive Imaging of Matrix Metalloproteinases
por: Breyholz, Hans-Jörg, et al.
Publicado: (2017)

1,3-Dimethyl-5-(2-methylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
por: Panchatcharam, R., et al.
Publicado: (2009)

β subunits of voltage-gated calcium channels in cardiovascular diseases
por: Loh, Kelvin Wei Zhern, et al.
Publicado: (2023)

5-[1-(1,3-Dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl)-2-oxopropyl]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
por: Sweidan, Kamal, et al.
Publicado: (2013)

Optogenetic Control of Voltage‐Gated Calcium Channels
por: Ma, Guolin, et al.
Publicado: (2018)

Functions of Presynaptic Voltage-gated Calcium Channels
por: Dolphin, Annette C
Publicado: (2020)

RGK regulation of voltage-gated calcium channels
por: Zafir, BURAEI, et al.
Publicado: (2015)

Rubidium 2,4,6-trioxo-1,3-diazinan-5-ide–1,3-diazinane-2,4,6-trione–water (1/1/1)
por: Gryl, Marlena, et al.
Publicado: (2011)

Calmodulin regulation (calmodulation) of voltage-gated calcium channels
por: Ben-Johny, Manu, et al.
Publicado: (2014)

Roles and Regulation of Voltage-gated Calcium Channels in Arrhythmias
por: Kushner, Jared, et al.
Publicado: (2019)

Structural determinants of voltage-gating properties in calcium channels
por: Fernández-Quintero, Monica L, et al.
Publicado: (2021)

Diverse organization of voltage-gated calcium channels at presynaptic active zones
por: Zhang, Weijia, et al.
Publicado: (2022)

5-(3,4-Dimethoxybenzylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione
por: Gohain, Mukut, et al.
Publicado: (2011)

How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity
por: Frank, C. Andrew
Publicado: (2014)

LRRK2 Regulates Voltage-Gated Calcium Channel Function
por: Bedford, Cade, et al.
Publicado: (2016)

Voltage‐gated calcium channels – from basic mechanisms to disease
por: Striessnig, Jörg
Publicado: (2016)

Voltage-Gated Calcium Channel Antagonists and Traumatic Brain Injury
por: Gurkoff, Gene, et al.
Publicado: (2013)

Voltage-gated calcium channels: Novel targets for cancer therapy
por: Phan, Nam Nhut, et al.
Publicado: (2017)

Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3
por: Gao, Yiwei, et al.
Publicado: (2023)

Theoretical and simulation studies on voltage-gated sodium channels
por: Li, Yang, et al.
Publicado: (2015)

Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia
por: Zhang, Qing, et al.
Publicado: (2018)

Upregulation of Voltage-Gated Calcium Channel Ca(v)1.3 in Bovine Somatotropes Treated with Ghrelin
por: Salinas Zarate, V. M., et al.
Publicado: (2013)

The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels
por: Calloway, Nathaniel, et al.
Publicado: (2015)

Crystal structure of 5,5-bis(4-methylbenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione monohydrate
por: Ravi Kiran, Bhaskarachar, et al.
Publicado: (2015)

Gating Mechanism of the Voltage-Gated Proton Channel Studied by Molecular Dynamics Simulations
por: Phan, Thi Tuong Vy, et al.
Publicado: (2022)

Thermodynamics of voltage-gated ion channels
por: Zhang, Xuejun C., et al.
Publicado: (2018)

Crystal structure of 5-[bis(methylsulfonyl)methyl]-1,3-dimethyl-5-(methylsulfonyl)pyrimidine-2,4,6(1H,3H,5H)-trione
por: Mallah, Eyad, et al.
Publicado: (2015)

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?
por: Flucher, Bernhard E., et al.
Publicado: (2017)

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
por: Heyes, Samuel, et al.
Publicado: (2015)

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
por: Campiglio, Marta, et al.
Publicado: (2015)

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology
por: Dolphin, Annette C.
Publicado: (2016)

Structural insights into binding of STAC proteins to voltage-gated calcium channels
por: Wong King Yuen, Siobhan M., et al.
Publicado: (2017)

Voltage-gated calcium channels: Their discovery, function and importance as drug targets
por: Dolphin, Annette C.
Publicado: (2018)

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders
por: Andrade, Arturo, et al.
Publicado: (2019)

Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels
por: Shi, Liheng, et al.
Publicado: (2017)

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
por: Harrison, Paul J., et al.
Publicado: (2020)

Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson’s Disease
por: Leandrou, Emmanouela, et al.
Publicado: (2019)

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels
por: Ferron, Laurent, et al.
Publicado: (2020)

An examination of plasma autoantibodies against voltage gated calcium channels in schizophrenia
por: McLean, Ryan Thomas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_90effk853brdm94f9m7bpilfo6