Cargando…

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes

Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%. High HbF levels are sometimes a result of β-globin gene deletions or point mutations in the promoters of the HbF genes. Collecti...

Descripción completa

Detalles Bibliográficos
Autor principal:	Steinberg, Martin H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700170/ https://www.ncbi.nlm.nih.gov/pubmed/33238542 http://dx.doi.org/10.3390/jcm9113782

Ejemplares similares

miRNA Expression Associated with HbF in Saudi Sickle Cell Anemia
por: Cyrus, Cyril, et al.
Publicado: (2022)

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
por: Finotti, Alessia, et al.
Publicado: (2023)

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
por: Zuccato, Cristina, et al.
Publicado: (2012)

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
por: Zuccato, Cristina, et al.
Publicado: (2023)

Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis
por: Sales, Rahyssa Rodrigues, et al.
Publicado: (2022)

FOETAL HAEMOGLOBIN (HbF) STATUS IN ADULT SICKLE CELL ANAEMIA PATIENTS IN IBADAN, NIGERIA
por: Olaniyi, J.A., et al.
Publicado: (2010)

Role of microRNA in hydroxyurea mediated HbF induction in sickle cell anaemia patients
por: Kargutkar, Neha, et al.
Publicado: (2023)

CNTO 530 Increases Expression of HbA and HbF in Murine Models of β-Thalassemia and Sickle Cell Anemia
por: Makropoulos, Dorie A, et al.
Publicado: (2013)

The Effect of Alpha Thalassemia, HbF and HbC on Haematological Parameters of Sickle Cell Disease Patients in Ibadan, Nigeria
por: Fasola, Foluke Atinuke, et al.
Publicado: (2022)

Genetic variants at HbF‐modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania
por: Mtatiro, Siana Nkya, et al.
Publicado: (2014)

Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh
por: Bhagat, Sanjana, et al.
Publicado: (2012)

HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines
por: Minniti, Caterina P., et al.
Publicado: (2020)

Genetic Variation on Chromosome 6 Influences F Cell Levels in Healthy Individuals of African Descent and HbF Levels in Sickle Cell Patients
por: Creary, Lisa E., et al.
Publicado: (2009)

Association of polymorphisms in the HBG1‐HBD intergenic region with HbF levels
por: Hu, Li, et al.
Publicado: (2020)

Combinatorial targeting of epigenome-modifying enzymes with decitabine and RN-1 synergistically increases HbF
por: Ibanez, Vinzon, et al.
Publicado: (2023)

Unique Polymorphisms at BCL11A, HBS1L-MYB and HBB Loci Associated with HbF in Kuwaiti Patients with Sickle Cell Disease
por: Akbulut-Jeradi, Nagihan, et al.
Publicado: (2021)

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders
por: Fard, Ali Dehghani, et al.
Publicado: (2013)

Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients
por: Cyrus, Cyril, et al.
Publicado: (2017)

Effect of Cis Acting Potential Regulators in the β Globin Gene Cluster on the Production of HbF in Thalassemia Patients
por: Dabke, Pooja, et al.
Publicado: (2013)

A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies
por: Peterson, Kenneth R., et al.
Publicado: (2014)

Chen J-J. HRI stress signaling and HbF production. Blood. 2020;135(24):2113-2114.
Publicado: (2020)

A Novel Association of HbQ India Trait with Sickle Cell Anemia: a New Insight in Hemoglobinopathies
por: Gupta, Rakesh K., et al.
Publicado: (2022)

Sickle cell hemoglobinopathies in district Bhopal
por: Dangi, C. B. S., et al.
Publicado: (2010)

Sickle Cell Disease and Fetal Hemoglobin
por: Rivera, Alicia
Publicado: (2018)

Evaluation of the Effect of miR-26b Up-Regulation on HbF Expression in Erythroleukemic K-562 Cell Line
por: Alijani, Sadegh, et al.
Publicado: (2014)

The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34(+) Cells from Sickle Cell Disease Patients
por: Drakopoulou, Ekati, et al.
Publicado: (2022)

Hb A1c Separation by High Performance Liquid Chromatography in Hemoglobinopathies
por: Chandrashekar, Vani
Publicado: (2016)

IthaPhen: An Interactive Database of Genotype-Phenotype Data for Hemoglobinopathies
por: Xenophontos, Maria, et al.
Publicado: (2023)

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells
por: Yu, Xiaofei, et al.
Publicado: (2019)

Comparison of in-vitro and in-vivo response to fetal hemoglobin production and γ-mRNA expression by hydroxyurea in Hemoglobinopathies
por: Italia, Khushnooma, et al.
Publicado: (2013)

Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia
por: Eridani, Sandro, et al.
Publicado: (2011)

Genomic approaches to identifying targets for treating β hemoglobinopathies
por: Ngo, Duyen A., et al.
Publicado: (2015)

Prevalence of hemoglobin variants in a diabetic population at high risk of hemoglobinopathies and optimization of HbA1c monitoring by incorporating HPLC in the laboratory workup
por: Bouzid, Kahena, et al.
Publicado: (2014)

The First Korean Hemoglobinopathy With Unique Hemoglobin Electrophoresis Results Diagnosed as Hemoglobin Boras
por: Bae, Jeongyun, et al.
Publicado: (2024)

Retinal thickness measurements in sickle cell patients with HbSS and HbSC genotype
por: Lim, Wei S., et al.
Publicado: (2018)

Hematological Parameters and Demographic Distribution of Hemoglobinopathies and Various Hemoglobin Variants
por: Shaikh, Israr A, et al.
Publicado: (2022)

Fetal hemoglobin and hemolysis markers in sickle cell anemia()
por: Colella, Marina Pereira, et al.
Publicado: (2015)

In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia
por: Iftikhar, Fizza, et al.
Publicado: (2022)

Diagnostic value of fetal hemoglobin Bart’s for evaluation of fetal α-thalassemia syndromes: application to prenatal characterization of fetal anemia caused by undiagnosed α-hemoglobinopathy
por: Singha, Kritsada, et al.
Publicado: (2022)

CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease
por: Demirci, Selami, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0ngt6bsu5ojt8qdol2gq6g96ul