Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge. Moreover, the insurgence rate of effective m...

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Detalles Bibliográficos
Autores principales: Gianquinto, Eleonora, Tondi, Donatella, D’Arrigo, Giulia, Lazzarato, Loretta, Spyrakis, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700307/
https://www.ncbi.nlm.nih.gov/pubmed/33233339
http://dx.doi.org/10.3390/antibiotics9110833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700307/
https://www.ncbi.nlm.nih.gov/pubmed/33233339
http://dx.doi.org/10.3390/antibiotics9110833

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