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Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge. Moreover, the insurgence rate of effective m...
Autores principales: | Gianquinto, Eleonora, Tondi, Donatella, D’Arrigo, Giulia, Lazzarato, Loretta, Spyrakis, Francesca |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700307/ https://www.ncbi.nlm.nih.gov/pubmed/33233339 http://dx.doi.org/10.3390/antibiotics9110833 |
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