Design, Synthesis, and Antitumor Activity of a Series of Novel 4-(Aromatic Sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones

Many sulfonamides show anticancer activity. Based on benzenesulfonylazaspirodienone (HL-X9) identified in our previous work, we optimized the lead compound for better efficacy, thereby synthesizing a series of novel 4-(aromatic sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-one derivatives through a...

Descripción completa

Detalles Bibliográficos
Autores principales: Xing, Naiguo, Chen, Chen, Zhong, Qiu, Zheng, Shilong, Wang, Guangdi, He, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700525/
https://www.ncbi.nlm.nih.gov/pubmed/33233396
http://dx.doi.org/10.3390/molecules25225459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700525/
https://www.ncbi.nlm.nih.gov/pubmed/33233396
http://dx.doi.org/10.3390/molecules25225459

Ejemplares similares