Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation

Clr4 is a histone H3 lysine 9 methyltransferase in Schizosaccharomyces pombe that is essential for heterochromatin formation. Previous biochemical and structural studies have shown that Clr4 is in an autoinhibited state in which an autoregulatory loop (ARL) blocks the active site. Automethylation of...

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Detalles Bibliográficos
Autores principales: Khella, Mina S., Bröhm, Alexander, Weirich, Sara, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700585/
https://www.ncbi.nlm.nih.gov/pubmed/33266419
http://dx.doi.org/10.3390/ijms21228832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700585/
https://www.ncbi.nlm.nih.gov/pubmed/33266419
http://dx.doi.org/10.3390/ijms21228832

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