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TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and analyzed cFLIP epidermal KO mice with additional TNF deficiency. Intriguingly, the ablation of TNF rescued the pathological phenotype of epidermal...

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Detalles Bibliográficos
Autores principales: Feoktistova, Maria, Makarov, Roman, Leverkus, Martin, Yazdi, Amir S., Panayotova-Dimitrova, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700656/
https://www.ncbi.nlm.nih.gov/pubmed/33238518
http://dx.doi.org/10.3390/ijms21228859