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Plasmin-Induced Activation of Human Platelets Is Modulated by Thrombospondin-1, Bona Fide Misfolded Proteins and Thiol Isomerases
Inflammatory processes are triggered by the fibrinolytic enzyme plasmin. Tissue-type plasminogen activator, which cleaves plasminogen to plasmin, can be activated by the cross-β-structure of misfolded proteins. Misfolded protein aggregates also represent substrates for plasmin, promoting their degra...
Autores principales: | Pielsticker, Claudia, Brodde, Martin F., Raum, Lisa, Jurk, Kerstin, Kehrel, Beate E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700677/ https://www.ncbi.nlm.nih.gov/pubmed/33238433 http://dx.doi.org/10.3390/ijms21228851 |
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