Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1

MTH1 (MutT homolog 1) or NUDT1 (Nudix Hydrolase 1), also known as oxidized purine nucleoside triphosphatase, has potential as a biomarker for monitoring cancer progression and quantifying target engagement for relevant therapies. In this study, we validate one MTH1 inhibitor TH287 as a PET MTH1 radi...

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Detalles Bibliográficos
Autores principales: Chen, Huaping, Afrin, Sadia, Guo, Yingqiu, Chu, Wenhua, Benzinger, Tammie L.S., Rogers, Buck E., Garbow, Joel R., Perlmutter, Joel S., Zhou, Dong, Xu, Jinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700685/
https://www.ncbi.nlm.nih.gov/pubmed/33238630
http://dx.doi.org/10.3390/ijms21228860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700685/
https://www.ncbi.nlm.nih.gov/pubmed/33238630
http://dx.doi.org/10.3390/ijms21228860

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