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Aryl Sulfonamides Induce Degradation of Aryl Hydrocarbon Receptor Nuclear Translocator through CRL4(DCAF15) E3 Ligase

Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress. Under conditions of hypoxia or xenobiotic exposure, ARNT regulates the subset of genes involved in adaptive responses, by forming heterodimers with h...

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Detalles Bibliográficos
Autores principales: Kim, Sung Ah, Jo, Seung-Hyun, Cho, Jin Hwa, Yu, Min Yeong, Shin, Ho-Chul, Kim, Jung-Ae, Park, Sung Goo, Park, Byoung Chul, Kim, Sunhong, Kim, Jeong-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700843/
https://www.ncbi.nlm.nih.gov/pubmed/33168788
http://dx.doi.org/10.14348/molcells.2020.0122