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Purification of a heterodimeric Reelin construct to investigate binding stoichiometry

Reelin is a secreted glycoprotein that is integral in neocortex development and synaptic function. Reelin exists as a homodimer with two chains linked by a disulfide bond at cysteine 2101, a feature that is vital to the protein’s function. This is highlighted by the fact that only dimeric Reelin can...

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Detalles Bibliográficos
Autores principales: Turk, Liam S., Mitchell, Daniel, Comoletti, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701066/
https://www.ncbi.nlm.nih.gov/pubmed/33057791
http://dx.doi.org/10.1007/s00249-020-01465-6