A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

Disruption of viral fusion represents a viable, albeit under-explored, target for HIV therapeutics. Here, while studying the receptor-bound envelope glycoprotein conformation by cryoelectron microscopy (cryo-EM), we identify a pocket near the base of the trimer containing a bound detergent molecule...

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Detalles Bibliográficos
Autores principales: Ozorowski, Gabriel, Torres, Jonathan L., Santos-Martins, Diogo, Forli, Stefano, Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701285/
https://www.ncbi.nlm.nih.gov/pubmed/33238117
http://dx.doi.org/10.1016/j.celrep.2020.108428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701285/
https://www.ncbi.nlm.nih.gov/pubmed/33238117
http://dx.doi.org/10.1016/j.celrep.2020.108428

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