Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

6-Phosphofructokinase-1-kinase (PFK) tetramers catalyse the phosphorylation of fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate (F16BP). Vertebrates have three PFK isoforms (PFK-M, PFK-L, and PFK-P). This study is the first to compare the kinetics, structures, and transcript levels of recombi...

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Detalles Bibliográficos
Autores principales: Fernandes, Peter M., Kinkead, James, McNae, Iain, Michels, Paul A.M., Walkinshaw, Malcolm D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702303/
https://www.ncbi.nlm.nih.gov/pubmed/33141153
http://dx.doi.org/10.1042/BCJ20200656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702303/
https://www.ncbi.nlm.nih.gov/pubmed/33141153
http://dx.doi.org/10.1042/BCJ20200656

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