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Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains

In humans, iatrogenic transmission of cerebral amyloid-β (Aβ)-amyloidosis is suspected following inoculation of pituitary-derived hormones or dural grafts presumably contaminated with Aβ proteins as well as after cerebral surgeries. Experimentally, intracerebral inoculation of brain homogenate extra...

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Detalles Bibliográficos
Autores principales: Hérard, Anne-Sophie, Petit, Fanny, Gary, Charlotte, Guillermier, Martine, Boluda, Susana, Garin, Clément M., Lam, Suzanne, Dhenain, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702698/
https://www.ncbi.nlm.nih.gov/pubmed/33250056
http://dx.doi.org/10.1186/s40478-020-01081-7