Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

Glucagon-like peptide-1 receptor (GLP-1R) agonists are efficacious antidiabetic medications that work by enhancing glucose-dependent insulin secretion and improving energy balance. Currently approved GLP-1R agonists are peptide based, and it has proven difficult to obtain small-molecule activators p...

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Detalles Bibliográficos
Autores principales: Kawai, Takahiro, Sun, Bingfa, Yoshino, Hitoshi, Feng, Dan, Suzuki, Yoshiyuki, Fukazawa, Masanori, Nagao, Shunsuke, Wainscott, David B., Showalter, Aaron D., Droz, Brian A., Kobilka, Tong Sun, Coghlan, Matthew P., Willard, Francis S., Kawabe, Yoshiki, Kobilka, Brian K., Sloop, Kyle W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703558/
https://www.ncbi.nlm.nih.gov/pubmed/33177239
http://dx.doi.org/10.1073/pnas.2014879117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703558/
https://www.ncbi.nlm.nih.gov/pubmed/33177239
http://dx.doi.org/10.1073/pnas.2014879117

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