Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. A high-...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wei, Chen, Chuan, Drelich, Aleksandra, Martinez, David R., Gralinski, Lisa E., Sun, Zehua, Schäfer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Leist, Sarah R., Zhelev, Doncho V., Zhang, Liyong, Kim, Ye-Jin, Peterson, Eric C., Conard, Alex, Mellors, John W., Tseng, Chien-Te K., Falzarano, Darryl, Baric, Ralph S., Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703590/
https://www.ncbi.nlm.nih.gov/pubmed/33139569
http://dx.doi.org/10.1073/pnas.2010197117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703590/
https://www.ncbi.nlm.nih.gov/pubmed/33139569
http://dx.doi.org/10.1073/pnas.2010197117

Ejemplares similares