Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

P-glycoprotein (P-gp), also known as ABCB1, is a cell membrane transporter that mediates the efflux of chemically dissimilar amphipathic drugs and confers resistance to chemotherapy in most cancers. Homologous transmembrane helices (TMHs) 6 and 12 of human P-gp connect the transmembrane domains with...

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Detalles Bibliográficos
Autores principales: Sajid, Andaleeb, Lusvarghi, Sabrina, Murakami, Megumi, Chufan, Eduardo E., Abel, Biebele, Gottesman, Michael M., Durell, Stewart R., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703596/
https://www.ncbi.nlm.nih.gov/pubmed/33168729
http://dx.doi.org/10.1073/pnas.2016270117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703596/
https://www.ncbi.nlm.nih.gov/pubmed/33168729
http://dx.doi.org/10.1073/pnas.2016270117

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