HypercubeME: two hundred million combinatorially complete datasets from a single experiment

MOTIVATION: Epistasis, the context-dependence of the contribution of an amino acid substitution to fitness, is common in evolution. To detect epistasis, fitness must be measured for at least four genotypes: the reference genotype, two different single mutants and a double mutant with both of the sin...

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Detalles Bibliográficos
Autores principales: Esteban, Laura A, Lonishin, Lyubov R, Bobrovskiy, Daniil M, Leleytner, Gregory, Bogatyreva, Natalya S, Kondrashov, Fyodor A, Ivankov, Dmitry N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Applications Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703787/
https://www.ncbi.nlm.nih.gov/pubmed/31742320
http://dx.doi.org/10.1093/bioinformatics/btz841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703787/
https://www.ncbi.nlm.nih.gov/pubmed/31742320
http://dx.doi.org/10.1093/bioinformatics/btz841

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