Cargando…
HypercubeME: two hundred million combinatorially complete datasets from a single experiment
MOTIVATION: Epistasis, the context-dependence of the contribution of an amino acid substitution to fitness, is common in evolution. To detect epistasis, fitness must be measured for at least four genotypes: the reference genotype, two different single mutants and a double mutant with both of the sin...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703787/ https://www.ncbi.nlm.nih.gov/pubmed/31742320 http://dx.doi.org/10.1093/bioinformatics/btz841 |