Cargando…

On the coherence of model-based dose-finding designs for drug combination trials

The concept of coherence was proposed for single-agent phase I clinical trials to describe the property that a design never escalates the dose when the most recently treated patient has toxicity and never de-escalates the dose when the most recently treated patient has no toxicity. It provides a use...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Yeonhee, Liu, Suyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703981/
https://www.ncbi.nlm.nih.gov/pubmed/33253260
http://dx.doi.org/10.1371/journal.pone.0242561