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On the coherence of model-based dose-finding designs for drug combination trials
The concept of coherence was proposed for single-agent phase I clinical trials to describe the property that a design never escalates the dose when the most recently treated patient has toxicity and never de-escalates the dose when the most recently treated patient has no toxicity. It provides a use...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703981/ https://www.ncbi.nlm.nih.gov/pubmed/33253260 http://dx.doi.org/10.1371/journal.pone.0242561 |