Cargando…

Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients

BACKGROUND: Sub-epithelial fibrosis is a characteristic feature of airway remodeling in asthma which correlates with disease severity. Current asthma medications are ineffective in treating fibrosis. In this study, we aimed to investigate the mitochondrial phenotype in fibroblasts isolated from airw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramakrishnan, Rakhee K., Bajbouj, Khuloud, Hachim, Mahmood Y., Mogas, Andrea K., Mahboub, Bassam, Olivenstein, Ronald, Hamoudi, Rifat, Halwani, Rabih, Hamid, Qutayba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704010/ https://www.ncbi.nlm.nih.gov/pubmed/33253229 http://dx.doi.org/10.1371/journal.pone.0242695

Ejemplares similares

IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts
por: Ramakrishnan, Rakhee K., et al.
Publicado: (2020)

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients
por: Ramakrishnan, Rakhee K., et al.
Publicado: (2022)

Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Author Correction: Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Action of 1,25(OH)(2)D(3) on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma
por: Plesa, Maria, et al.
Publicado: (2020)

Contribution of IL-17 in Steroid Hyporesponsiveness in Obese Asthmatics Through Dysregulation of Glucocorticoid Receptors α and β
por: Al Heialy, Saba, et al.
Publicado: (2020)

Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients
por: Mahboub, Bassam, et al.
Publicado: (2021)

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics
por: Poon, Audrey H., et al.
Publicado: (2017)

Neutrophils from severe asthmatic patients induce epithelial to mesenchymal transition in healthy bronchial epithelial cells
por: Haddad, Alexandre, et al.
Publicado: (2019)

Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology
por: Hammoudeh, Sarah Musa, et al.
Publicado: (2021)

Editorial: Biomarkers in Pulmonary Diseases
por: Mahboub, Bassam, et al.
Publicado: (2022)

Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease
por: Mdkhana, Bushra, et al.
Publicado: (2023)

ACE2 polymorphisms impact COVID-19 severity in obese patients
por: Jalaleddine, Nour, et al.
Publicado: (2022)

Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Asthma Associated Cytokines Regulate the Expression of SARS-CoV-2 Receptor ACE2 in the Lung Tissue of Asthmatic Patients
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2022)

Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19
por: Ramakrishnan, Rakhee K., et al.
Publicado: (2021)

Continuous positive airway pressure therapy suppresses inflammatory cytokines and improves glucocorticoid responsiveness in patients with obstructive sleep apnea and asthma: A case–control study
por: Mahboub, Bassam, et al.
Publicado: (2022)

Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients
por: Hammoudeh, Sarah Musa, et al.
Publicado: (2021)

SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression
por: Goel, Swati, et al.
Publicado: (2021)

Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality
por: Mdkhana, Bushra, et al.
Publicado: (2021)

Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2021)

Innate Lymphoid Cells and Natural Killer Cells in Bacterial Infections: Function, Dysregulation, and Therapeutic Targets
por: Elemam, Noha Mousaad, et al.
Publicado: (2021)

The Role of Systems Biology in Deciphering Asthma Heterogeneity
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2022)

Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function
por: Ansari, Abdul Wahid, et al.
Publicado: (2020)

Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

Cardiovascular medications and regulation of COVID-19 receptors expression
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2021)

Asthma severity as a contributing factor to cancer incidence: A cohort study
por: Salameh, Laila, et al.
Publicado: (2021)

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

The Molecular Basis of Gender Variations in Mortality Rates Associated With the Novel Coronavirus (COVID-19) Outbreak
por: Hachim, Ibrahim Y., et al.
Publicado: (2021)

Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
por: Al Heialy, Saba, et al.
Publicado: (2020)

Differences in MAP kinase phosphorylation in response to mechanical strain in asthmatic fibroblasts
por: Le Bellego, Frédérique, et al.
Publicado: (2006)

Altered respiratory microbiota composition and functionality associated with asthma early in life
por: AL Bataineh, Mohammad T., et al.
Publicado: (2020)

Transcriptomic Changes Associated with ERBB2 Overexpression in Colorectal Cancer Implicate a Potential Role of the Wnt Signaling Pathway in Tumorigenesis
por: Abdul Razzaq, Eman A., et al.
Publicado: (2022)

The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review
por: Salameh, Laila, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fg6evum3tiktlf0tt1tstlu5d3