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IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration

Chronic activation of microglia is associated with retinal degeneration, which makes them a potential therapeutic target for retinal degenerative diseases including age-related macular degeneration (AMD). Interferon-beta (IFN-β) is a potent immune regulator, commonly used for the treatment of multip...

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Detalles Bibliográficos
Autores principales: Behnke, Verena, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704411/
https://www.ncbi.nlm.nih.gov/pubmed/33299932
http://dx.doi.org/10.1016/j.bbrep.2020.100866