Direct binding of TFEα opens DNA binding cleft of RNA polymerase

Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP, RNAP-TFEα binary, and RNAP-TFEα-promoter DNA ternary complexes fro...

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Detalles Bibliográficos
Autores principales: Jun, Sung-Hoon, Hyun, Jaekyung, Cha, Jeong Seok, Kim, Hoyoung, Bartlett, Michael S., Cho, Hyun-Soo, Murakami, Katsuhiko S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704642/
https://www.ncbi.nlm.nih.gov/pubmed/33257704
http://dx.doi.org/10.1038/s41467-020-19998-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704642/
https://www.ncbi.nlm.nih.gov/pubmed/33257704
http://dx.doi.org/10.1038/s41467-020-19998-x

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