Cargando…

Direct binding of TFEα opens DNA binding cleft of RNA polymerase

Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP, RNAP-TFEα binary, and RNAP-TFEα-promoter DNA ternary complexes fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jun, Sung-Hoon, Hyun, Jaekyung, Cha, Jeong Seok, Kim, Hoyoung, Bartlett, Michael S., Cho, Hyun-Soo, Murakami, Katsuhiko S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704642/ https://www.ncbi.nlm.nih.gov/pubmed/33257704 http://dx.doi.org/10.1038/s41467-020-19998-x

Ejemplares similares

Archaeal TFEα/β is a hybrid of TFIIE and the RNA polymerase III subcomplex hRPC62/39
por: Blombach, Fabian, et al.
Publicado: (2015)

Structural and functional adaptation of Haloferax volcanii TFEα/β
por: Blombach, Fabian, et al.
Publicado: (2018)

Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter
por: Miao, Beiping, et al.
Publicado: (2021)

TFE3-Expressing Perivascular Epithelioid Cell Tumor of the Breast
por: Kim, Hyunjin, et al.
Publicado: (2019)

Polymerase manager protein UmuD directly regulates Escherichia coli DNA polymerase III α binding to ssDNA
por: Chaurasiya, Kathy R., et al.
Publicado: (2013)

The X-ray crystal structure of the euryarchaeal RNA polymerase in an open clamp configuration
por: Jun, Sung-Hoon, et al.
Publicado: (2014)

Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3
por: Dang, Thao Thi, et al.
Publicado: (2021)

NRF-1 directly regulates TFE3 and promotes the proliferation of renal cancer cells
por: Zhuang, Wenyuan, et al.
Publicado: (2021)

The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis
por: Manohar, Kodavati, et al.
Publicado: (2021)

Disruption of an AP-2α binding site in an IRF6 enhancer is strongly associated with cleft lip
por: Rahimov, Fedik, et al.
Publicado: (2008)

A missense allele of KARRIKIN-INSENSITIVE2 impairs ligand-binding and downstream signaling in Arabidopsis thaliana
por: Lee, Inhye, et al.
Publicado: (2018)

Structural Biology of Bacterial RNA Polymerase
por: Murakami, Katsuhiko S.
Publicado: (2015)

MiT/TFE Family Renal Cell Carcinoma
por: Tang, Jinglong, et al.
Publicado: (2023)

Emerging roles of TFE3 in metabolic regulation
por: Li, Xingyu, et al.
Publicado: (2023)

The NTP binding site of the polymerase ribozyme
por: Akoopie, Arvin, et al.
Publicado: (2018)

The TFE-induced transient native-like structure of the intrinsically disordered [Formula: see text] domain of Escherichia coli RNA polymerase
por: Kaczka, Piotr, et al.
Publicado: (2014)

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α
por: Han, Hyeong-jun, et al.
Publicado: (2016)

Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2
por: Kim, Tae Yoon, et al.
Publicado: (2021)

Anion Binding Studies of Urea and Thiourea Functionalized Molecular Clefts
por: Manna, Utsab, et al.
Publicado: (2021)

Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif
por: Kim, Kuglae, et al.
Publicado: (2016)

The suitability of NONO-TFE3 dual-fusion FISH assay as a diagnostic tool for NONO-TFE3 renal cell carcinoma
por: Liu, Ning, et al.
Publicado: (2020)

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases
por: Zhang, Pamela, et al.
Publicado: (2012)

RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template
por: Pai, Dave A., et al.
Publicado: (2014)

Emerging roles and regulation of MiT/TFE transcriptional factors
por: Yang, Min, et al.
Publicado: (2018)

MiT/TFE Family of Transcription Factors: An Evolutionary Perspective
por: La Spina, Martina, et al.
Publicado: (2021)

Study of Treatment Outcome in Adults with TFE-Related RCC
por: Singh, Ajaykumar Chandrabhan, et al.
Publicado: (2021)

TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
por: Di Malta, Chiara, et al.
Publicado: (2023)

BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
por: Bae, Seung-Hyun, et al.
Publicado: (2022)

Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II
por: Meinel, Dominik M., et al.
Publicado: (2013)

Interaction of ZEB and Histone Deacetylase with the PLDLS-binding cleft region of monomeric C-terminal Binding Protein 2
por: Zhao, Ling-Jun, et al.
Publicado: (2009)

Impact of HLA-DR Antigen Binding Cleft Rigidity on T Cell Recognition
por: Szeto, Christopher, et al.
Publicado: (2020)

Epithelioid hemangioendotheliomas with TFE3 gene translocations are compossible with CAMTA1 gene rearrangements
por: Lee, Seok Joo, et al.
Publicado: (2016)

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
por: Pflug, Alexander, et al.
Publicado: (2018)

A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion
por: Ye, Hong, et al.
Publicado: (2019)

DNA binding fluorescent proteins for the direct visualization of large DNA molecules
por: Lee, Seonghyun, et al.
Publicado: (2016)

Hepatic YAP1-TFE3 Rearranged Epithelioid Hemangioendothelioma
por: Lotfalla, Mira M., et al.
Publicado: (2019)

GaMD simulations as an alternative in the TFE-water mixture description
por: Pérez-Trejo, Itzel, et al.
Publicado: (2023)

NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma
por: Pei, Jianming, et al.
Publicado: (2019)

PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue
por: Xiong, Lei, et al.
Publicado: (2017)

DNA sequencing using polymerase substrate-binding kinetics
por: Previte, Michael John Robert, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j7pchlli9fcr8f6mra1dp1thql