Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations

Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSM...

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Detalles Bibliográficos
Autores principales: Nait Saada, Juba, Kalantzis, Georgios, Shyr, Derek, Cooper, Fergus, Robinson, Martin, Gusev, Alexander, Palamara, Pier Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704644/
https://www.ncbi.nlm.nih.gov/pubmed/33257650
http://dx.doi.org/10.1038/s41467-020-19588-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704644/
https://www.ncbi.nlm.nih.gov/pubmed/33257650
http://dx.doi.org/10.1038/s41467-020-19588-x

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