NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Beginning at early stages, human Alzheimer’s disease (AD) brains manifest hyperexcitability, contributing to subsequent extensive synapse loss, which has been linked to cognitive dysfunction. No current therapy for AD is disease-modifying. Part of the problem with AD drug discovery is that transgeni...

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Detalles Bibliográficos
Autores principales: Ghatak, Swagata, Dolatabadi, Nima, Gao, Richard, Wu, Yin, Scott, Henry, Trudler, Dorit, Sultan, Abdullah, Ambasudhan, Rajesh, Nakamura, Tomohiro, Masliah, Eliezer, Talantova, Maria, Voytek, Bradley, Lipton, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704704/
https://www.ncbi.nlm.nih.gov/pubmed/32467645
http://dx.doi.org/10.1038/s41380-020-0776-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704704/
https://www.ncbi.nlm.nih.gov/pubmed/32467645
http://dx.doi.org/10.1038/s41380-020-0776-7

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