Theophylline Dosing and Pharmacokinetics for Renal Protection in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia

BACKGROUND: Theophylline, a non-selective adenosine receptor antagonist, improves renal perfusion in the setting of hypoxia-ischemia and may offer therapeutic benefit in neonates with hypoxic ischemic encephalopathy (HIE) undergoing hypothermia. We evaluated the pharmacokinetics and dose-exposure re...

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Detalles Bibliográficos
Autores principales: Frymoyer, Adam, Van Meurs, Krisa P., Drover, David R., Klawitter, Jelena, Christians, Uwe, Chock, Valerie Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704857/
https://www.ncbi.nlm.nih.gov/pubmed/32919393
http://dx.doi.org/10.1038/s41390-020-01140-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704857/
https://www.ncbi.nlm.nih.gov/pubmed/32919393
http://dx.doi.org/10.1038/s41390-020-01140-8

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