The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

Pathogen-derived nucleic acids induce potent innate immune responses(1-6). Cyclic GMP-AMP synthase (cGAS) is a dsDNA sensor that catalyzes the synthesis of a cyclic dinucleotide cGAMP, which mediates the induction of type I interferons through the STING-TBK1-IRF3 signaling axis(7-11). It was widely...

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Detalles Bibliográficos
Autores principales: Zhao, Baoyu, Xu, Pengbiao, Rowlett, Chesley M., Jing, Tao, Shinde, Omkar, Lei, Yuanjiu, West, A. Phillip, Liu, Wenshe Ray, Li, Pingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704945/
https://www.ncbi.nlm.nih.gov/pubmed/32911481
http://dx.doi.org/10.1038/s41586-020-2749-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704945/
https://www.ncbi.nlm.nih.gov/pubmed/32911481
http://dx.doi.org/10.1038/s41586-020-2749-z

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