Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic pathway

M. tuberculosis GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose biosynthetic pathway. The D-glycero-α-D-manno-heptose is a major constituent of lipopolysaccharide and contributes to virulence and a...

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Detalles Bibliográficos
Autores principales: Karan, Sumita, Pratap, Bhanu, Yadav, Shiv Pratap, Ashish, FNU, Saxena, Ajay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705670/
https://www.ncbi.nlm.nih.gov/pubmed/33257730
http://dx.doi.org/10.1038/s41598-020-77230-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705670/
https://www.ncbi.nlm.nih.gov/pubmed/33257730
http://dx.doi.org/10.1038/s41598-020-77230-8

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