IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis

Inflammatory signaling is thought to modulate the neurodegenerative cascade in amyotrophic lateral sclerosis (ALS). We have previously shown that expression of Interleukin-10 (IL-10), a classical anti-inflammatory cytokine, extends lifespan in the SOD1-G93A mouse model of familial ALS. Here we test...

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Detalles Bibliográficos
Autores principales: Strickland, Michael R., Ibanez, Kristen R., Yaroshenko, Mariya, Diaz, Carolina Ceballos, Borchelt, David R., Chakrabarty, Paramita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705692/
https://www.ncbi.nlm.nih.gov/pubmed/33257786
http://dx.doi.org/10.1038/s41598-020-77564-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705692/
https://www.ncbi.nlm.nih.gov/pubmed/33257786
http://dx.doi.org/10.1038/s41598-020-77564-3

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