Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, it is not clear how this complex is regulated at other subcellular locations. Here, we combi...

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Detalles Bibliográficos
Autores principales: Zhou, Xin, Zhong, Yanghao, Molinar-Inglis, Olivia, Kunkel, Maya T., Chen, Mingyuan, Sun, Tengqian, Zhang, Jiao, Shyy, John Y.-J., Trejo, JoAnn, Newton, Alexandra C., Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705703/
https://www.ncbi.nlm.nih.gov/pubmed/33257668
http://dx.doi.org/10.1038/s41467-020-19937-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705703/
https://www.ncbi.nlm.nih.gov/pubmed/33257668
http://dx.doi.org/10.1038/s41467-020-19937-w

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