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Incorporation of a metal-mediated base pair into an ATP aptamer – using silver(I) ions to modulate aptamer function
For the first time, a metal-mediated base pair has been used to modulate the affinity of an aptamer towards its target. In particular, two artificial imidazole 2’-deoxyribonucleosides (Im) were incorporated into various positions of an established ATP-binding aptamer (ATP, adenosine triphosphate), r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705865/ https://www.ncbi.nlm.nih.gov/pubmed/33299485 http://dx.doi.org/10.3762/bjoc.16.236 |