Fluorine effect in nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-β-D-hexopyranose

In this work, we have developed a simple synthetic approach using Et(3)N·3HF as an alternative to the DAST reagent. We controlled the stereochemistry of the nucleophilic fluorination at C4 of 1,6-anhydro-2,3-dideoxy-2,3-difluoro-4-O-triflate-β-ᴅ-talopyranose using Et(3)N·3HF or in situ generated Et(...

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Detalles Bibliográficos
Autores principales: Lainé, Danny, Denavit, Vincent, Lessard, Olivier, Carrier, Laurie, Fecteau, Charles-Émile, Johnson, Paul A, Giguère, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705882/
https://www.ncbi.nlm.nih.gov/pubmed/33299486
http://dx.doi.org/10.3762/bjoc.16.237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705882/
https://www.ncbi.nlm.nih.gov/pubmed/33299486
http://dx.doi.org/10.3762/bjoc.16.237

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